[CAS NO. 38030-57-8] all-trans-4-Oxoretinoic acid
PRODUCTS SPECIFICATIONS [38030-57-8]
DESCRIPTION [38030-57-8]
Overview
| MDL | MFCD00870472 |
|---|---|
| Molecular Weight | 314.42 |
| Molecular Formula | C20H26O3 |
| SMILES | CC(/C=C/C=C(/C=C/C1=C(C(CCC(C)1C)=O)C)C)=C\C(O)=O |
Summary
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs) [1] . all-trans-4-Oxoretinoic acid is a biologically active geometric isomer of retinoic acid (RA) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 159.02 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1805 mL | 15.9023 mL | 31.8046 mL |
| 5 mM | 0.6361 mL | 3.1805 mL | 6.3609 mL |
| 10 mM | 0.3180 mL | 1.5902 mL | 3.1805 mL |
References
- [1] Topletz AR, et al. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Mol Pharmacol. 2015;87(3):430-41.
- [2] Stahl W, et al. 4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells. Adv Exp Med Biol. 1996;387:121-8.
Synonyms
