[CAS NO. 38136-70-8] Brevianamide F

Name: Brevianamide F
Brand: Arctom Scientific
SKU: HY-100385

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PRODUCTS SPECIFICATIONS [38136-70-8]

Fulfillment

Catalog

HY-100385

Brand

MCE

CAS

38136-70-8

DESCRIPTION [38136-70-8]

Overview

MDL	MFCD29917326
Molecular Weight	283.33
Molecular Formula	C16H17N3O2
SMILES	O=C(N[C@H]1CC2=CNC3=C2C=CC=C3)[C@@](CCC4)([H])N4C1=O

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides , with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC ₅₀ of 4.8 µM ^[1] ^[2] .

IC50 & Target

PI3Kα

4.8 μM (IC ₅₀ )

In Vitro

Brevianamide F shows moderate activity against both MSSA and MRSA ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Colletotrichum gloeosporioides

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 176.47 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5295 mL	17.6473 mL	35.2945 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.82 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-indol-3-ylmethyl)-, (3S,8aS)-

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(1H-indol-3-ylmethyl)-, (3S-trans)-

(3S,8aS)-Hexahydro-3-(1H-indol-3-ylmethyl)pyrrolo[1,2-a]pyrazine-1,4-dione

Brevianamide F

Cyclo-L-tryptophyl-L-proline

cyclo-L-Prolyl-L-tryptophanyl

L-Prolyl-L-tryptophan anhydride

Prolyltryptophanyldiketopiperazine

Cyclo(L-Pro-L-Trp)

Cyclo-L-Trp-L-Pro