[CAS NO. 40013-87-4] 24,25-DihydroxyVD3

Name: 24,25-DihydroxyVD3
Brand: Arctom Scientific
SKU: AS296009

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PRODUCTS SPECIFICATIONS [40013-87-4]

Distributor

Catalog

AS296009

Brand

Arctom Scientific

CAS

40013-87-4

DESCRIPTION [40013-87-4]

Overview

MDL	-
Molecular Weight	416.64
Molecular Formula	C27H44O3
SMILES	C=C1/C(C[C@@H](O)CC1)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCC(O)C(C)(C)O)CC3

For research use only. We do not sell to patients.

Summary

24, 25-Dihydroxy VD3 is a compound closely related to 1,25-dihydroxyvitamin D3 and is the active form of vitamin D3 ^[1] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

24, 25-Dihydroxy VD3 (24R,25(OH)2D3) (0.002-202 nM) inhibits the increase in intracellular Ca ²⁺ concentration in a dose-dependent manner, with an EC ₅₀ of 4.9 nM and a maximum inhibition rate of 60% in Atlantic cod of both sexes intestinal cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 120.01 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4002 mL	12.0008 mL	24.0015 mL
5 mM	0.4800 mL	2.4002 mL	4.8003 mL
10 mM	0.2400 mL	1.2001 mL	2.4002 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] D Larsson, et al. Antagonistic effects of 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 on L-type Ca2+ channels and Na+/Ca2+ exchange in enterocytes from Atlantic cod (Gadus morhua). J Mol Endocrinol. 2002 Feb;28(1):53-68.

Synonyms

2,3-Heptanediol, 2-methyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-, (6R)-

9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol, (3β,5Z,7E)-

(6R)-2-Methyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-2,3-heptanediol

24,25-Dihydroxyvitamin D₃

24,25-Dihydroxyvitamin D

24-Hydroxycalcidiol

(3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol