[CAS NO. 40533-25-3] Cyclapolin9
PRODUCTS SPECIFICATIONS [40533-25-3]
DESCRIPTION [40533-25-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 307.21 |
| Molecular Formula | C9H4F3N3O4S |
| SMILES | O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N |
Summary
Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC 50 of 500 nM. Cyclapolin 9 is inactive against other kinases [1] [2] .
IC50 & Target
|
PLK1 500 nM (IC 50 ) |
In Vitro
Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 5 mg/mL ( 16.28 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2551 mL | 16.2755 mL | 32.5510 mL |
| 5 mM | 0.6510 mL | 3.2551 mL | 6.5102 mL |
| 10 mM | 0.3255 mL | 1.6276 mL | 3.2551 mL |
References
