[CAS NO. 408303-43-5] GW 766994

Name: GW 766994
Brand: Arctom Scientific
SKU: AS947703

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PRODUCTS SPECIFICATIONS [408303-43-5]

Fulfillment

Catalog

AS947703

Brand

Arctom Scientific

CAS

408303-43-5

DESCRIPTION [408303-43-5]

Overview

MDL	-
Molecular Weight	451.35
Molecular Formula	C21H24Cl2N4O3
SMILES	NC(C(C=C1)=CC=C1CNC(NC[C@H](OCC2)CN2CC3=CC(Cl)=C(Cl)C=C3)=O)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Cell Mol Immunol. 2020 Jul;17(7):753-764.

Summary

GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research ^[1] ^[2] .

IC50 & Target

CCR3

7.86 (pKi)

In Vitro

GW 766994 is a specific chemokine receptor-3 (CCR3) antagonist, which has entered clinical trial for asthma and eosinophilic bronchitis ^[1] . GW 766994 (10 μM) reverses CCL11-induced activation of CDK5, phosphorylations of CDK5, GSK3β, and increased phosphorylation of tau in hippocampal neurons ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 56 mg/mL ( 124.07 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2156 mL	11.0779 mL	22.1558 mL
5 mM	0.4431 mL	2.2156 mL	4.4312 mL
10 mM	0.2216 mL	1.1078 mL	2.2156 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.33 mg/mL (5.16 mM); Clear solution

* All of the co-solvents are available by MCE.