[CAS NO. 41307-63-5] Resorcinolnaphthalein
PRODUCTS SPECIFICATIONS [41307-63-5]
DESCRIPTION [41307-63-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 382.36 |
| Molecular Formula | C24H14O5 |
| SMILES | O=C1C2=CC=CC3=C2C(C4(C5=C(OC6=C4C=CC(O)=C6)C=C(O)C=C5)O1)=CC=C3 |
Summary
Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC 50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis [1] .
IC50 & Target
EC50: 19.5 μM (ACE2) [1]
In Vitro
Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC
50
values of 19.5 μM and 20.1 μM, respectively
[1]
.
ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 326.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6153 mL | 13.0767 mL | 26.1534 mL |
| 5 mM | 0.5231 mL | 2.6153 mL | 5.2307 mL |
| 10 mM | 0.2615 mL | 1.3077 mL | 2.6153 mL |
