[CAS NO. 4143-62-8] 3',4'-Dimethoxyflavone

Name: 3',4'-Dimethoxyflavone
Brand: Arctom Scientific
SKU: AS522595

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PRODUCTS SPECIFICATIONS [4143-62-8]

Distributor

Catalog

AS522595

Brand

Arctom Scientific

CAS

4143-62-8

DESCRIPTION [4143-62-8]

Overview

MDL	MFCD00143009
Molecular Weight	282.29
Molecular Formula	C17H14O4
SMILES	O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC=CC=C13

For research use only. We do not sell to patients.

Summary

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris . 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects ^[1] ^[2] ^[3] ^[4] .

IC50 & Target

PARP, Aryl hydrocarbon receptor ^[1]

In Vitro

3',4'-Dimethoxyflavone (10 and 20 μM) has protection against the reduction in SH-SY5Y viability induced by Methylnitronitrosoguanidine (MNNG) (HY-128612) ^[2] .
3',4'-Dimethoxyflavone (6.25-25 μM) decreases the levels of PAR induced by MNNG in HeLa cells ^[2] .
3',4'-Dimethoxyflavone (12.5, 25, 50 and 100 μM; 15-20 h) reduces cortical neuronal death induced by exposure to NMDA (HY-17551) ^[2] .
3',4'-Dimethoxyflavone (0.1-10 μM; 24 h) exhibits significant inhibition of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced EROD activity in MCF-7 and T47D cells ^[3] .
3',4'-Dimethoxyflavone inhibits AhR-dependent CYP1A1 induction and AhR-mediated inhibition of estrogen-induced gene expression in T47D and MCF-7 breast cancer cells ^[3] .
3′,4′-Dimethoxyflavone (2.5 μM; 7 days) promotes the proliferation of human hematopoietic stem cells ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:	Primary cortical neurones (isolated from fetal CD1 mice, incubated with NMDA)
Concentration:	12.5, 25, 50 and 100 μM
Incubation Time:	15-20 h
Result:	Reduced concentration-dependently neuronal death induced by exposure to NMDA.

Cell Proliferation Assay ^[4]

Cell Line:	CD ³⁴⁺ cells
Concentration:	2.5 μM
Incubation Time:	7 days
Result:	Induced a significantly higher amplification of the CD ³⁴⁺ population under normoxia.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL ( 177.12 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5425 mL	17.7123 mL	35.4246 mL
5 mM	0.7085 mL	3.5425 mL	7.0849 mL
10 mM	0.3542 mL	1.7712 mL	3.5425 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (8.86 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-

Flavone, 3′,4′-dimethoxy-

2-(3,4-Dimethoxyphenyl)-4H-1-benzopyran-4-one

3′,4′-Dimethoxyflavone

2-(3,4-Dimethoxyphenyl)-4H-chromen-4-one

2-(3,4-Dimethoxyphenyl)chromen-4-one