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[CAS NO. 4192-90-9] Trilobatin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-N4100 |
| Brand: | MCE |
| CAS: | 4192-90-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 436.41 |
| Molecular Formula | C21H24O10 |
| SMILES | OC(C=C1)=CC=C1CCC(C2=C(C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2O)O)=O |
1 Publications Citing Use of MCE
Summary
Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd [1] , Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope [2] . Neuroprotective effects [1] . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells [3] .
IC50 & Target
|
HIV-1
|
SGLT1
|
SGLT2
|
In Vitro
Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL ( 286.43 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2914 mL | 11.4571 mL | 22.9142 mL |
| 5 mM | 0.4583 mL | 2.2914 mL | 4.5828 mL |
| 10 mM | 0.2291 mL | 1.1457 mL | 2.2914 mL |
References
- [1] Gao J, et al. Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci. 2018 Jul 30;11:267.
- [2] Yin S, et al. Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett. 2018 Jul;592(13):2361-2377.
Synonyms
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