[CAS NO. 4201-22-3] Tolonidine
PRODUCTS SPECIFICATIONS [4201-22-3]
DESCRIPTION [4201-22-3]
Overview
| MDL | MFCD00865890 |
|---|---|
| Molecular Weight | 209.68 |
| Molecular Formula | C10H12ClN3 |
| SMILES | CC1=CC=C(NC2=NCCN2)C(Cl)=C1 |
Summary
Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties [1] .
In Vivo
In the anesthetized dog, tolonidine administered i.v. decreases the amplitude of ventricular contractions, reduces aortic blood flow and increases peripheral vascular resistances
[1]
.
In the bivagotomized pithed rat, tolonidine induces a long-lasting increase in blood pressure with no secondary hypotension, thus suggesting peripheral sympathomimetic properties
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 476.92 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.7692 mL | 23.8459 mL | 47.6917 mL |
| 5 mM | 0.9538 mL | 4.7692 mL | 9.5383 mL |
| 10 mM | 0.4769 mL | 2.3846 mL | 4.7692 mL |
Synonyms
