[CAS NO. 4291-60-5] Tilianin

Name: Tilianin
Brand: Arctom Scientific
SKU: AS078868

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PRODUCTS SPECIFICATIONS [4291-60-5]

Distributor

Catalog

AS078868

Brand

Arctom Scientific

CAS

4291-60-5

DESCRIPTION [4291-60-5]

Overview

MDL	MFCD00238695
Molecular Weight	446.40
Molecular Formula	C22H22O10
SMILES	O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2OC(C4=CC=C(OC)C=C4)=C1

For research use only. We do not sell to patients.

Summary

Tilianin is an active flavonoid glycoside found in many medical plants , with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects ^[1] ^[2] ^[3] .

In Vitro

Tilianin (10 μM, 20 μM) reduced secretion of LPS (1 μg/mL)-induced proinflammatory cytokine in RAW264.7 macrophage cell ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tilianin (10 mg/kg; i.p.) is a potential agent for ameliorating LPS-induced acute lung injury (ALI) ^[2] .
Tilianin shows T _max =10.8 min, C _max =176.9 nmol/L, AUC _0-∞ = 17.4 min*μmol/L in mice ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mouse ^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection
Result:	Attenuated infiltration of macrophages and histopathological changes and improved inflammation.

Animal Model:	Male FVB mice (6-10 weeks) ^[3]
Dosage:	10 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral gavage
Result:	T _max (10.8 min), C _max (176.9 nmol/L), AUC _0-∞ (17.4 min*μmol/L).

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 112.01 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2401 mL	11.2007 mL	22.4014 mL
5 mM	0.4480 mL	2.2401 mL	4.4803 mL
10 mM	0.2240 mL	1.1201 mL	2.2401 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.66 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.66 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-

Tilianin

7-(β-D-Glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Moldavoside

Acacetin 7-O-β-D-glucopyranoside

Acacetin 7-O-glucoside

Acacetin 7-glucoside

Astroside

7-O-β-D-Glucopyranosyl-4′-methylapigenin

Acacetin 7-O-β-D-glucoside

Apigenin-7-O-β-D-glucopyranoside-4′-O-methyl ether

Tilianine

Clerodendronone 1b