[CAS NO. 443639-96-1] S119-8
PRODUCTS SPECIFICATIONS [443639-96-1]
DESCRIPTION [443639-96-1]
Overview
| MDL | MFCD01121291 |
|---|---|
| Molecular Weight | 344.45 |
| Molecular Formula | C23H24N2O |
| SMILES | O=C(NC1=CC=C(NC2=CC=CC=C2)C=C1)C3=CC=C(C(C)(C)C)C=C3 |
Summary
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV) [1] .
IC50 & Target
Influenza A and B [1]
In Vitro
S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC 50 =1.43 μM) at non-toxic (CC 50 =66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC 50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC 50 of 8.42 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 150 mg/mL ( 435.48 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9032 mL | 14.5159 mL | 29.0318 mL |
| 5 mM | 0.5806 mL | 2.9032 mL | 5.8064 mL |
| 10 mM | 0.2903 mL | 1.4516 mL | 2.9032 mL |
