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[CAS NO. 482-39-3] Afzelin

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Catalog:	HY-N1441
Brand:	MCE
CAS:	482-39-3

Overview

MDL	MFCD00210589
Molecular Weight	432.38
Molecular Formula	C21H20O10
SMILES	O=C1C(O[C@H]2[C@@H]([C@@H]([C@H]([C@H](C)O2)O)O)O)=C(C3=CC=C(O)C=C3)OC4=CC(O)=CC(O)=C14

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Aging (Albany NY). 2021 Nov 25;13(22):24753-24767.

Summary

Afzelin (Kaempferol-3-O-rhamnoside) is is a flavonol glycoside found in Houttuynia cordata Thunberg and is widely used in the preparation of antibacterial and antipyretic agents, detoxicants and for the treatment of inflammation. Afzelin attenuates the mitochondrial damage , enhances mitochondrial biogenesis and decreases the level of mitophagy-related proteins , parkin and PTEN-induced putative kinase 1 . Afzelin improves the survival rate and reduces the serum levels of alanine aminotransferase and pro-inflammatory cytokines in D-galactosamine (GalN)/LPS -treated mice ^[1] .

Appearance

Solid

Source

Plants
Saururaceae
Houttuynia cordata Thunb.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

Ethanol : 12.5 mg/mL ( 28.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3128 mL	11.5639 mL	23.1278 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% EtOH >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution
2.

Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution
3.

Add each solvent one by one: 10% EtOH >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.78 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Lee SB, et al. Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. Br J Pharmacol. 2017 Jan;174(2):195-209.

Synonyms

4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-

Afzelin

3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Kaempferol 3-rhamnoside

Kaempferol 3-L-rhamnoside

Afzeloside

Kaempferol 3-O-rhamnoside

Kaempferol 3-O-α-L-rhamnopyranoside

Kaempferol 3-α-L-rhamnopyranoside

Kaempferol 3-O-α-L-rhamnoside

Kaempferin

Kaempherol 3-O-α-L-rhamnopyranoside

Kaempferol rhamnoside

Kaempferol 3-(6-deoxy-L-mannopyranoside)

Kaempherol 3-O-α-rhamnoside

3-O-α-L-Rhamnopyranosylkaempferol

Kaempferol 3-O-rhamnopyranoside

Kaempferol-3-α-L-rhamnose

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