[CAS NO. 484-29-7] Dictamine
PRODUCTS SPECIFICATIONS [484-29-7]
DESCRIPTION [484-29-7]
Overview
| MDL | MFCD00221742 |
|---|---|
| Molecular Weight | 199.21 |
| Molecular Formula | C12H9NO2 |
| SMILES | COC1=C2C(OC=C2)=NC3=CC=CC=C13 |
Summary
Dictamnine (Dictamine) has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma cells; A natural plant product has been reported to have antimicrobial activity against bacteria and fungi. IC50 value: Target: Dictamnine has antimicrobial activities against the model fungus Saccharomyces cerevisiae, with a minimum inhibitory concentration (MIC) value of 64 microg/ml [1]. Dic induced S phase cell cycle arrest at low concentration and cell apoptosis at high concentration in which loss of mitochondrial membrane potential (Δψmm) was not involved. In addition, inhibition of caspase-3 using the specific inhibitor, z-DQMD-fmk, did not attenuate Dic-induced apoptosis , implying that Dic-induced caspase-3-independent apoptosis [2].
Appearance
Solid
Source
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 250.99 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.0198 mL | 25.0991 mL | 50.1983 mL |
| 5 mM | 1.0040 mL | 5.0198 mL | 10.0397 mL |
| 10 mM | 0.5020 mL | 2.5099 mL | 5.0198 mL |
References
- [1] Guo N, et al. Global gene expression profile of Saccharomyces cerevisiae induced by dictamnine. Yeast. 2008 Sep;25(9):631-41.
- [2] An FF, et al. Dihydroartemisinine enhances dictamnine-induced apoptosis via a caspase dependent pathway in human lung adenocarcinoma A549 cells. Asian Pac J Cancer Prev. 2013;14(10):5895-900.
Synonyms
