[CAS NO. 494830-67-0] NIC3
PRODUCTS SPECIFICATIONS [494830-67-0]
DESCRIPTION [494830-67-0]
Overview
| MDL | MFCD03542891 |
|---|---|
| Molecular Weight | 440.58 |
| Molecular Formula | C26H36N2O4 |
| SMILES | CC(C)(C)C1=CC=C(OCC(NCCNC(COC2=CC=C(C(C)(C)C)C=C2)=O)=O)C=C1 |
Summary
NIC3 is a selective nucleus accumbens-associated protein-1 ( NAC1 ) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity [1] .
IC50 & Target
NAC1 [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 113.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2697 mL | 11.3487 mL | 22.6974 mL |
| 5 mM | 0.4539 mL | 2.2697 mL | 4.5395 mL |
| 10 mM | 0.2270 mL | 1.1349 mL | 2.2697 mL |
-
1.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (5.67 mM); Clear solution
