[CAS NO. 496775-95-2]  ML-099

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PRODUCTS SPECIFICATIONS [496775-95-2]

Store
Catalog
AS689911
Brand
Arctom Scientific
CAS
496775-95-2

DESCRIPTION [496775-95-2]

Overview

MDLMFCD03621206
Molecular Weight259.32
Molecular FormulaC14H13NO2S
SMILESOC(C1=CC=CN=C1SCCC2=CC=CC=C2)=O

For research use only. We do not sell to patients.

Summary

ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1 , cell division cycle 42 , Ras , Rab7 , and Rab-2A [1] .


In Vitro

ML-099 activates cell division cycle 42 activated mutant, cell division cycle 42 wild type, Ras protein wild type, GTP-binding protein (Rab7), Rab-2A, Rac1 protein activated mutant, Rac1 protein wild type, and Ras protein activated mutant with EC 50 values of 58.88 nM, 100 nM, 141.25 nM, 181.97 nM, 354.81 nM, 25.42 nM, 20.17 nM and 95.5 nM, respectively [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 385.62 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8562 mL 19.2812 mL 38.5624 mL
5 mM 0.7712 mL 3.8562 mL 7.7125 mL
10 mM 0.3856 mL 1.9281 mL 3.8562 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

* All of the co-solvents are available by MCE.