[CAS NO. 500565-15-1] HM03
PRODUCTS SPECIFICATIONS [500565-15-1]
DESCRIPTION [500565-15-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 462.97 |
| Molecular Formula | C26H27ClN4O2 |
| SMILES | OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5 |
Summary
IC50 & Target
|
HSPA5 |
In Vitro
HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells
[1]
.
HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins
[1]
.
HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | HCT116 cells |
| Concentration: | 0.1, 1, 10, 25, 50 μM |
| Incubation Time: | 72 hours |
| Result: | Exhibited prominent inhibition effect (18% survival at 25 µM). |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 125 mg/mL ( 270.00 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1600 mL | 10.7998 mL | 21.5997 mL |
| 5 mM | 0.4320 mL | 2.1600 mL | 4.3199 mL |
| 10 mM | 0.2160 mL | 1.0800 mL | 2.1600 mL |
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1.
