[CAS NO. 5122-36-1] FAPy-adenine
PRODUCTS SPECIFICATIONS [5122-36-1]
DESCRIPTION [5122-36-1]
Overview
| MDL | MFCD00047382 |
|---|---|
| Molecular Weight | 153.14 |
| Molecular Formula | C5H7N5O |
| SMILES | O=CNC1=C(N)N=CN=C1N |
Summary
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 17.86 mg/mL ( 116.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.5300 mL | 32.6499 mL | 65.2997 mL |
| 5 mM | 1.3060 mL | 6.5300 mL | 13.0599 mL |
| 10 mM | 0.6530 mL | 3.2650 mL | 6.5300 mL |
References
- [1] Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease.
- [2] Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45.
- [3] Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7.
Synonyms
