[CAS NO. 51460-26-5] Carbazochromesodiumsulfonate
PRODUCTS SPECIFICATIONS [51460-26-5]
DESCRIPTION [51460-26-5]
Overview
| MDL | MFCD00867493 |
|---|---|
| Molecular Weight | 322.27 |
| Molecular Formula | C10H11N4NaO5S |
| SMILES | O=S(C(CC1=C/C2=N/NC(N)=O)N(C)C1=CC2=O)(O[Na])=O |
Summary
Carbazochrome sodium sulfonate (AC-17) is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome sodium sulfonate is an antihemorrhagic agent [1] .
In Vitro
Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [ 3 H]IP3 in a concentration-dependent manner [1] . Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats weighing 180-230 g [2] |
| Dosage: | 1, 5 and 10 mg/kg |
| Administration: | I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.). |
| Result: | Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 49 mg/mL ( 152.05 mM )
H 2 O : 6.67 mg/mL ( 20.70 mM ; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1030 mL | 15.5149 mL | 31.0299 mL |
| 5 mM | 0.6206 mL | 3.1030 mL | 6.2060 mL |
| 10 mM | 0.3103 mL | 1.5515 mL | 3.1030 mL |
References
- [1] Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80.
- [2] Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8.
Synonyms
