[CAS NO. 518044-36-5]  Mal-PEG4-Boc

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PRODUCTS SPECIFICATIONS [518044-36-5]

Distributor
Catalog
AS107043
Brand
Arctom Scientific
CAS
518044-36-5

DESCRIPTION [518044-36-5]

Overview

MDLMFCD22683300
Molecular Weight401.45
Molecular FormulaC19H31NO8
SMILESO=C(OC(C)(C)C)CCOCCOCCOCCOCCN1C(C=CC1=O)=O

For research use only. We do not sell to patients.

Summary

Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs

Alkyl/ether


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Oil


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 249.10 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4910 mL 12.4549 mL 24.9097 mL
5 mM 0.4982 mL 2.4910 mL 4.9819 mL
10 mM 0.2491 mL 1.2455 mL 2.4910 mL
* Please refer to the solubility information to select the appropriate solvent.


Synonyms

4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester
1,1-Dimethylethyl 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-4,7,10,13-tetraoxapentadecanoate