[CAS NO. 52-24-4] Thio-TEPA
PRODUCTS SPECIFICATIONS [52-24-4]
DESCRIPTION [52-24-4]
Overview
| MDL | MFCD00145452 |
|---|---|
| Molecular Weight | 189.22 |
| Molecular Formula | C6H12N3PS |
| SMILES | S=P(N1CC1)(N2CC2)N3CC3 |
Summary
Thio-TEPA is a DNA alkylating agent, with antitumor activity.
IC50 & Target
DNA Alkylator [1]
In Vitro
Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 50 mg/mL ( 264.24 mM )
H 2 O : < 0.1 mg/mL (insoluble)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2849 mL | 26.4243 mL | 52.8485 mL |
| 5 mM | 1.0570 mL | 5.2849 mL | 10.5697 mL |
| 10 mM | 0.5285 mL | 2.6424 mL | 5.2849 mL |
References
- [1] Hagen B, et al. Metabolism and alkylating activity of thio-TEPA in rat liver slice incubation. Cancer Chemother Pharmacol. 1991;28(6):441-7.
- [2] Down JD, et al. Thiotepa improves allogeneic bone marrow engraftment without enhancing stem cell depletion in irradiated mice. Bone Marrow Transplant. 1998 Feb;21(4):327-30.
Synonyms