[CAS NO. 52452-60-5] Terphenyllin

Name: Terphenyllin
Brand: Arctom Scientific
SKU: AS937418

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PRODUCTS SPECIFICATIONS [52452-60-5]

Distributor

Catalog

AS937418

Brand

Arctom Scientific

CAS

52452-60-5

DESCRIPTION [52452-60-5]

Overview

MDL	-
Molecular Weight	338.35
Molecular Formula	C20H18O5
SMILES	OC1=CC=C(C=C1)C2=C(C(O)=C(C(OC)=C2)C3=CC=C(C=C3)O)OC

For research use only. We do not sell to patients.

Summary

Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus , has signiﬁcant α-glucosidase inhibitory activity ^[1] .

IC50 & Target

α-glucosidase ^[1]

Appearance

Solid

Source

Aspergillus candidus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL ( 246.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9555 mL	14.7776 mL	29.5552 mL
5 mM	0.5911 mL	2.9555 mL	5.9110 mL
10 mM	0.2956 mL	1.4778 mL	2.9555 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhang XQ, et al. Design, semisynthesis, α-glucosidase inhibitory, cytotoxic, and antibacterial activities of p-terphenyl derivatives. Eur J Med Chem. 2018 Feb 25;146:232-244.

Synonyms

[1,1′:4′,1′′-Terphenyl]-2′,4,4′′-triol, 3′,6′-dimethoxy-

3′,6′-Dimethoxy[1,1′:4′,1′′-terphenyl]-2′,4,4′′-triol

1,4-Dimethoxy-2,4′,4′′-trihydroxy-p-terphenyl

Terphenyllin

NSC 299114

2,5-Bis(4-hydroxyphenyl)-3,6-dimethoxyphenol