[CAS NO. 537034-15-4] NKL 22
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [537034-15-4]
Distributor
Catalog
AS908345
Brand
Arctom Scientific
CAS
537034-15-4
DESCRIPTION [537034-15-4]
Overview
| MDL | MFCD16293760 |
|---|---|
| Molecular Weight | 325.40 |
| Molecular Formula | C19H23N3O2 |
| SMILES | O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0731 mL | 15.3657 mL | 30.7314 mL |
| 5 mM | 0.6146 mL | 3.0731 mL | 6.1463 mL |
| 10 mM | 0.3073 mL | 1.5366 mL | 3.0731 mL |
| 50 mM | 0.0615 mL | 0.3073 mL | 0.6146 mL |
Description
NKL 22 is a selective inhibitor of with IC50 of 78 µM.
Targets
| HDAC [1] (Cell-free assay) |
| 78 μM |
In vitro
2.5 μM of NKL 22 increases frataxin protein concentrations in the FRDA ymphoid cell line. Incubation for 2 d in culture with NKL 22 increases the FXN mRNA level in lymphocytes from the affected individual to about 80% of that in lymphocytes from the unaffected individual. NKL 22 is highly active in increasing FXN mRNA levels in cells obtained from both carrier C and affected AC, bringing the FXN mRNA level in the FRDA lymphocytes to about 160% of that found in the untreated carrier lymphocytes..
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.