[CAS NO. 539-86-6] Allicin
PRODUCTS SPECIFICATIONS [539-86-6]
DESCRIPTION [539-86-6]
Overview
| MDL | MFCD00468100 |
|---|---|
| Molecular Weight | 162.27 |
| Molecular Formula | C6H10OS2 |
| SMILES | C=CCS(SCC=C)=O |
2 Publications Citing Use of MCE
Summary
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms , among them antibiotic-resistant strains [1] [2] .
In Vitro
Allicin exhibits comparable MICs (32-64 μg/mL) toward methicillin-resistant S. aureus ATCC 43300, the type strain S. aureus DSM 20231, E. coli DSM 30083, A. baumannii DSM 30007, and C. albicans DSM 1386 [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00122889 | Fred Hutchinson Cancer Center|National Center for Complementary and Integrative Health (NCCIH) |
Healthy
|
July 2005 | |
| NCT00029250 | National Center for Complementary and Integrative Health (NCCIH) |
HIV Infections|Hypercholesterolemia|Hypertriglyceridemia|Hyperglycemia
|
November 2001 | Phase 2 |
| NCT00455416 | Oslo University Hospital|University of Oslo |
Follicular Lymphoma
|
April 2007 | Phase 2 |
| NCT04545879 | National Taiwan University Hospital |
Atherosclerosis
|
March 18, 2019 | Not Applicable |
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 130 mg/mL ( 801.13 mM ; Need ultrasonic)
Ethanol : 70 mg/mL ( 431.38 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.1626 mL | 30.8128 mL | 61.6257 mL |
| 5 mM | 1.2325 mL | 6.1626 mL | 12.3251 mL |
| 10 mM | 0.6163 mL | 3.0813 mL | 6.1626 mL |
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1.
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2.
Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 3.5 mg/mL (21.57 mM); Clear solution
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3.
Add each solvent one by one: 10% EtOH >> 90% corn oil
Solubility: ≥ 3.5 mg/mL (21.57 mM); Clear solution
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4.
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5.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 3.25 mg/mL (20.03 mM); Clear solution
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6.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 3.25 mg/mL (20.03 mM); Clear solution
References
- [1] Rahman, et al. Allicin and Other Functional Active Components in Garlic: Health Benefits and Bioavailability[J]. International Journal of Food Properties, 2007, 10(2):245-268.
- [2] Müller A, et al. Allicin Induces Thiol Stress in Bacteria through S-Allylmercapto Modification of ProteinCysteines. J Biol Chem. 2016 May 27;291(22):11477-90.
Synonyms
