[CAS NO. 54-91-1] Pipobroman

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PRODUCTS SPECIFICATIONS [54-91-1]

Catelog

HY-16398

Brand

MCE

CAS

54-91-1

DESCRIPTION [54-91-1]

Overview

MDL	MFCD00866372
Molecular Weight	356.05
Molecular Formula	C10H16Br2N2O2
SMILES	O=C(N1CCN(C(CCBr)=O)CC1)CCBr

For research use only. We do not sell to patients.

Summary

Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent . Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 36 mg/mL ( 101.11 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8086 mL	14.0430 mL	28.0859 mL
5 mM	0.5617 mL	2.8086 mL	5.6172 mL
10 mM	0.2809 mL	1.4043 mL	2.8086 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.84 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Propanone, 1,1′-(1,4-piperazinediyl)bis[3-bromo-

Piperazine, 1,4-bis(3-bromopropionyl)-

Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-

1,1′-(1,4-Piperazinediyl)bis[3-bromo-1-propanone]

NSC-25154

1,4-Bis(3-bromopropionyl)piperazine

N,N′-Bis(3-bromopropionyl)piperazine

Pipobroman

Vercyte

A 1803

Amedel

1,1′-(Piperazine-1,4-diyl)bis(3-bromopropan-1-one)

1,4-Di(3-bromopropionyl)piperazine

3-Bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one