[CAS NO. 54149-17-6] m-PEG2-Br

Name: m-PEG2-Br
Brand: Arctom Scientific
SKU: AS594801

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PRODUCTS SPECIFICATIONS [54149-17-6]

Distributor

Catalog

AS594801

Brand

Arctom Scientific

CAS

54149-17-6

DESCRIPTION [54149-17-6]

Overview

MDL	MFCD00000238
Molecular Weight	183.04
Molecular Formula	C5H11BrO2
SMILES	COCCOCCBr

For research use only. We do not sell to patients.

Summary

m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Synonyms

Ethane, 1-(2-bromoethoxy)-2-methoxy-

1-(2-Bromoethoxy)-2-methoxyethane

2-(2-Methoxyethoxy)ethyl bromide

2-Bromoethyl 2-methoxyethyl ether

1-Bromo-3,6-dioxaheptane

1-Bromo-2-(2-methoxyethoxy)ethane

7-Bromo-2,5-dioxaheptane

1-Bromo-2-[1-[2-(methyloxy)ethyl]oxy]ethane

1-Bromo-2-[[2-(methyloxy)ethyl]oxy]ethane

2-(2′-Methoxyethoxy)ethyl bromide