[CAS NO. 54276-21-0] (+)-Cloprostenol

Name: (+)-Cloprostenol
Brand: Arctom Scientific
SKU: AS165088

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PRODUCTS SPECIFICATIONS [54276-21-0]

Distributor

Catalog

AS165088

Brand

Arctom Scientific

CAS

54276-21-0

DESCRIPTION [54276-21-0]

Overview

MDL	-
Molecular Weight	424.92
Molecular Formula	C22H29ClO6
SMILES	OC(CCC/C=C\C[C@@H]1[C@H]([C@H](O)C[C@@H]1O)/C=C/[C@@H](O)COC2=CC(Cl)=CC=C2)=O

For research use only. We do not sell to patients.

Summary

(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor .

IC50 & Target

PGF _2α

In Vitro

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [ ³ H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Oil

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 235.34 mM ; Need ultrasonic)

Ethanol : 50 mg/mL ( 117.67 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3534 mL	11.7669 mL	23.5338 mL
5 mM	0.4707 mL	2.3534 mL	4.7068 mL
10 mM	0.2353 mL	1.1767 mL	2.3534 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 5 mg/mL (11.77 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5 mg/mL (11.77 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5 mg/mL (11.77 mM); Clear solution
4.

Add each solvent one by one: 10% EtOH >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
5.

Add each solvent one by one: 10% EtOH >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution
6.

Add each solvent one by one: 10% EtOH >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.88 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)-

5-Heptenoic acid, 7-[2-[4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-, [1R-[1α(Z),2β(1E,3R*),3α,5α]]-

5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl]-3,5-dihydroxycyclopentyl]-, (5Z)-

(5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid

16-(m-Chlorophenoxy)-17,18,19,20-tetranorprostaglandin F_2α

d-Cloprostenol

(+)-Cloprostenol

Dalmazin

Prolise

Dalmaprost D

D-cloprostenol

Sinchron D