[CAS NO. 54504-70-0] Etofylline clofibrate

Name: Etofylline clofibrate
Brand: Arctom Scientific
SKU: AS661855

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PRODUCTS SPECIFICATIONS [54504-70-0]

Distributor

Catalog

AS661855

Brand

Arctom Scientific

CAS

54504-70-0

DESCRIPTION [54504-70-0]

Overview

MDL	MFCD00865733
Molecular Weight	420.85
Molecular Formula	C19H21ClN4O5
SMILES	ClC(C=C1)=CC=C1OC(C)(C)C(OCCN2C3=C(N(C(N(C)C3=O)=O)C)N=C2)=O

For research use only. We do not sell to patients.

Summary

Etofylline clofibrate has ypolipidemic and antithrombotic effect. Etofylline clofibrate has an agonistic interaction with intimal PGI2 ^[1] .

In Vivo

Etofylline clofibrate (p.o.; 12 mg/kg) has the moderate effect of a single dose (12% reduction in disaggregation time) and has a maximum reduction of 31 and 43% following 5 and 7 consecutive daily applications, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 52 mg/mL ( 123.56 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3761 mL	11.8807 mL	23.7614 mL
5 mM	0.4752 mL	2.3761 mL	4.7523 mL
10 mM	0.2376 mL	1.1881 mL	2.3761 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.17 mg/mL (5.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.17 mg/mL (5.16 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.17 mg/mL (5.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Metz G, et al. Effect of etofylline clofibrate on experimental thrombus formation and prostacyclin activation. Arzneimittelforschung. 1986 Sep;36(9):1363-5.

Synonyms

Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester

ML 1024

Etofylline clofibrate

Duolip

Theofibrate

Etophylline clofibrate

Ethophylline clofibrate

NSC 234348

2-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate