[CAS NO. 546-80-5] α-Thujone
PRODUCTS SPECIFICATIONS [546-80-5]
DESCRIPTION [546-80-5]
Overview
| MDL | MFCD00001313 |
|---|---|
| Molecular Weight | 152.23 |
| Molecular Formula | C10H16O |
| SMILES | O=C1C[C@]2(C(C)C)C[C@]2([H])[C@H]1C |
Summary
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC 50 for α-Thujone is 21 μM in suppressing the GABA -induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy . α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier [1] [2] [3] .
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 656.90 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.5690 mL | 32.8450 mL | 65.6901 mL |
| 5 mM | 1.3138 mL | 6.5690 mL | 13.1380 mL |
| 10 mM | 0.6569 mL | 3.2845 mL | 6.5690 mL |
References
- [1] Agus HH, et al. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe). FEMS Yeast Res. 2020 Apr 29. pii: foaa022.
- [2] Pudełek M, et al. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro. Fitoterapia. 2019 Apr;134:172-181.
- [3] Höld KM, et al. Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3826-31.
Synonyms
