[CAS NO. 55366-56-8] Hibifolin

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PRODUCTS SPECIFICATIONS [55366-56-8]

Catalog

HY-N7368

Brand

MCE

CAS

55366-56-8

DESCRIPTION [55366-56-8]

Overview

MDL	-
Molecular Weight	494.36
Molecular Formula	C21H18O14
SMILES	O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=C3C(C(C(O)=C(C4=CC=C(O)C(O)=C4)O3)=O)=C(O)C=C2O

For research use only. We do not sell to patients.

Summary

Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA) , with a K _i of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity ^[1] ^[2] .

IC50 & Target

Ki: 49.92 μM (ADA) ^[1]

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 202.28 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0228 mL	10.1141 mL	20.2282 mL
5 mM	0.4046 mL	2.0228 mL	4.0456 mL
10 mM	0.2023 mL	1.0114 mL	2.0228 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.06 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.06 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

Synonyms

β-D-Glucopyranosiduronic acid, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl

2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4-oxo-4H-1-benzopyran-8-yl β-D-glucopyranosiduronic acid

Hibifolin

Gossypetin 8-O-β-D-glucuronide