[CAS NO. 55683-37-9] Propargyl-PEG1-acid

Name: Propargyl-PEG1-acid
Brand: Arctom Scientific
SKU: AS457174

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PRODUCTS SPECIFICATIONS [55683-37-9]

Distributor

Catalog

AS457174

Brand

Arctom Scientific

CAS

55683-37-9

DESCRIPTION [55683-37-9]

Overview

MDL	MFCD10689189
Molecular Weight	128.13
Molecular Formula	C6H8O3
SMILES	O=C(O)CCOCC#C

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Biochem Biophys Res Commun. 21 July 2022.

Summary

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM ^[1] .

IC50 & Target

PEGs

In Vitro

BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Viscous liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.