[CAS NO. 5614-64-2] 8-Hydroxyguanine
PRODUCTS SPECIFICATIONS [5614-64-2]
DESCRIPTION [5614-64-2]
Overview
| MDL | MFCD00005564 |
|---|---|
| Molecular Weight | 167.13 |
| Molecular Formula | C5H5N5O2 |
| SMILES | O=C1NC(N)=NC2=C1NC(N2)=O |
Summary
8-Hydroxyguanine is a major pre-mutagenic lesion generated from reactive oxygen species . It causes G-T and A-C substitutions.
IC50 & Target
|
Human Endogenous Metabolite |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : < 1 mg/mL (insoluble)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
H 2 O : < 0.1 mg/mL (insoluble)
* 8-Hydroxyguanine is usually formulated as a suspension.
References
- [1] Arai T, et al. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002 Dec;23(12):2005-10.
- [2] Floyd RA, et al. The role of 8-hydroxyguanine in carcinogenesis. Carcinogenesis. 1990 Sep;11(9):1447-50.
- [3] Cheng KC, et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem. 1992 Jan 5;267(1):166-72.
Synonyms
