[CAS NO. 57396-78-8] Oroxin A

Name: Oroxin A
Brand: Arctom Scientific
SKU: AS031308

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PRODUCTS SPECIFICATIONS [57396-78-8]

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Catalog

AS031308

Brand

Arctom Scientific

CAS

57396-78-8

DESCRIPTION [57396-78-8]

Overview

MDL	MFCD22125001
Molecular Weight	432.38
Molecular Formula	C21H20O10
SMILES	O=C1C=C(C2=CC=CC=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=C(O)C(O)=C13

For research use only. We do not sell to patients.

Summary

Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE). Oroxin A acts as a partial PPARγ agonist that can activate PPARγ transcriptional activation. Oroxin A activates PPARγ by docking into the PPARγ protein ligand-binding domain. Oroxin A also exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity ^[1] . Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence ^[2] .

IC50 & Target

PPARγ

In Vitro

Oroxin A (0.5- 100 μM; 24 hours) significantly increases the PPARγ transcription level and exhibits the strongest activation with 50 μM in HEK-293t cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 289.10 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3128 mL	11.5639 mL	23.1278 mL
5 mM	0.4626 mL	2.3128 mL	4.6256 mL
10 mM	0.2313 mL	1.1564 mL	2.3128 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.81 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5,6-dihydroxy-2-phenyl-

7-(β-D-Glucopyranosyloxy)-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Baicalein 7-O-β-D-glucopyranoside

Biacalein 7-O-glucoside

5,6,7-Trihydroxyflavone 7-O-β-D-glucopyranoside

Baicalein 7-O-β-D-glucoside

Baicalein-7-O-glucoside

Baikalin

Oroxin A

Deglucosyloroxin B

Baicalein 7-O-glucopyranoside