[CAS NO. 593274-97-6] IntegrinAntagonists27
PRODUCTS SPECIFICATIONS [593274-97-6]
DESCRIPTION [593274-97-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 444.44 |
| Molecular Formula | C24H20N4O5 |
| SMILES | O=C(O)C1=CC=CC(N2C(/C=C(C(N3CC(NC4=CC=C(C)C=C4)=O)=O)\NC3=O)=CC=C2)=C1 |
Summary
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. Target: Integrin in vitro: Integrin Antagonists 27 is treated with a panel of cancer cell-lines (breast cancer cell line MDA-MB-435, breast cancer cell lines MCF-7, mouse fibroblast NIH3T3, ovarian cancer cell line HEY, lung cancer cell line NCI-H1975) with all IC50 of >20 uM.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 225.00 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2500 mL | 11.2501 mL | 22.5002 mL |
| 5 mM | 0.4500 mL | 2.2500 mL | 4.5000 mL |
| 10 mM | 0.2250 mL | 1.1250 mL | 2.2500 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: 2.5 mg/mL (5.63 mM); Clear solution; Need ultrasonic
