[CAS NO. 60560-33-0] Pinacidil
PRODUCTS SPECIFICATIONS [60560-33-0]
DESCRIPTION [60560-33-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 245.32 |
| Molecular Formula | C13H19N5 |
| SMILES | CC(C(C)(C)C)N/C(NC1=CC=NC=C1)=N\C#N |
2 Publications Citing Use of MCE
Summary
Pinacidil is a potent activator of potassium channel . Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K + -channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy [1] .
IC50 & Target
potassium channel [1]
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 407.63 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0763 mL | 20.3815 mL | 40.7631 mL |
| 5 mM | 0.8153 mL | 4.0763 mL | 8.1526 mL |
| 10 mM | 0.4076 mL | 2.0382 mL | 4.0763 mL |
References
- [1] Grover GJ, et al. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther. 1989;251(1):98-104.
- [2] Hamilton TC, et al. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20(1):1-9.
Synonyms
