[CAS NO. 6159-05-3] DHBP dibromide
PRODUCTS SPECIFICATIONS [6159-05-3]
DESCRIPTION [6159-05-3]
Overview
| MDL | MFCD00011997 |
|---|---|
| Molecular Weight | 514.38 |
| Molecular Formula | C24H38Br2N2 |
| SMILES | CCCCCCC[N+]1=CC=C(C2=CC=[N+](CCCCCCC)C=C2)C=C1.[Br-].[Br-] |
Summary
DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
In Vitro
DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC 50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [ 3 H]-ryanodine binding in a dose-dependent manner with an IC 50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 194.41 mM ; Need ultrasonic)
DMSO : ≥ 30 mg/mL ( 58.32 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9441 mL | 9.7204 mL | 19.4409 mL |
| 5 mM | 0.3888 mL | 1.9441 mL | 3.8882 mL |
| 10 mM | 0.1944 mL | 0.9720 mL | 1.9441 mL |
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1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (97.20 mM); Clear solution; Need ultrasonic
Synonyms
