[CAS NO. 62666-20-0] Progabide
PRODUCTS SPECIFICATIONS [62666-20-0]
DESCRIPTION [62666-20-0]
Overview
| MDL | MFCD01740869 |
|---|---|
| Molecular Weight | 334.77 |
| Molecular Formula | C17H16ClFN2O2 |
| SMILES | O=C(N)CCC/N=C(C1=CC=C(Cl)C=C1)\C2=CC(F)=CC=C2O |
Summary
Progabide is a gamma-aminobutyric acid receptor ( GABA ) agonist.
IC50 & Target
GABA receptor [1]
In Vivo
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 746.78 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9871 mL | 14.9356 mL | 29.8713 mL |
| 5 mM | 0.5974 mL | 2.9871 mL | 5.9743 mL |
| 10 mM | 0.2987 mL | 1.4936 mL | 2.9871 mL |
Synonyms
