[CAS NO. 63074-08-8] Terazosin HCl

Name: Terazosin HCl
Brand: Arctom Scientific
SKU: AS063849

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PRODUCTS SPECIFICATIONS [63074-08-8]

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Catalog

AS063849

Brand

Arctom Scientific

CAS

63074-08-8

DESCRIPTION [63074-08-8]

Overview

MDL	MFCD00467965
Molecular Weight	423.89
Molecular Formula	C19H25N5O4.HCl
SMILES	NC=1C2=C(N=C(N1)N3CCN(C(=O)C4CCCO4)CC3)C=C(OC)C(OC)=C2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3591 mL	11.7955 mL	23.5910 mL
5 mM	0.4718 mL	2.3591 mL	4.7182 mL
10 mM	0.2359 mL	1.1796 mL	2.3591 mL
50 mM	0.0472 mL	0.2359 mL	0.4718 mL

Description

Terazosin (Hytrin, Zayasel, Terazosine, Flumarc, Fosfomic, Blavin) is a selective antagonist used for treatment of symptoms of an enlarged prostate (BPH). It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Targets

alpha1-AR ^[1]

In vitro

Terazosin induces cytotoxicity in PC-3 and human benign prostatic cells with an IC50 of more than 100 μM. Terazosin also effectively inhibited vascular endothelial growth factor induced proliferation and tube formation in cultured human umbilical vein endothelial cells (IC50 9.9 and 6.8 μM, respectively).

In vivo

Terazosin produces a dose-dependent, complete inhibition of motor activity and catalepsy. Intraventricularly administered this antagonist protects striatal and cerebral cortical alpha 1 receptors but not striatal or cortical D1 receptors from in vivo alkylation by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroxyquinoline. Intraventricular terazosin also produces hypothermia and a reduced respiratory rate suggestive of a reduced sympathetic outflow. Terazosin does not impair performance on a horizontal wire test or the ability to make co-ordinated movements in a swim test.Terazosin significantly inhibits vascular endothelial growth factor induced angiogenesis in nude mice with an IC50 of 7.9 μM, showing that it has a more potent anti-angiogenic than cytotoxic effect.

References

[1] Robert Papay, et al. Journal of Neurochemistry. 2002, 83:623-634.
[2] Stone EA, et al. Neuroscience. 1999, 94(4):1245-52.
[3] Pan SL, et al. J Urol. 2003, 169(2):724-9.

Synonyms

Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-, hydrochloride (1:1)

Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, monohydrochloride

2-[4-(Tetrahydro-2-furoyl)-piperazine]-4-amino-6,7-dimethoxyquinazoline-hydrochloride

Terazosin hydrochloride

Hytrin

Vasocard

Abbott 45975

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine monohydrochloride

Terasin

Hytracin

Olyster

Dysalfa

Tructum

Heitrin

Vicard

Hytrine

Hytrinex

Itrin

Teralfa

Vasomet

Flotrin

Hitrin

Rotiaz

Flumarc

Terazin