[CAS NO. 6320-51-0] Pim-1/2 kinase inhibitor 1
PRODUCTS SPECIFICATIONS [6320-51-0]
DESCRIPTION [6320-51-0]
Overview
| MDL | MFCD00447556 |
|---|---|
| Molecular Weight | 235.26 |
| Molecular Formula | C11H9NO3S |
| SMILES | O=C(NC1=O)SC1=CC2=CC=C(OC)C=C2 |
Summary
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides , and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 Kip1 . Pim-1/2 kinase inhibitor 1 can be used in study of cancer , especially prostate cancer [1] .
In Vitro
Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 µM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Cytotoxicity Assay [1]
| Cell Line: | PC3 cells |
| Concentration: | varying concentrations |
| Incubation Time: | 48 h |
| Result: | Inhibited PC3 cells with an IC of 11 µM. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 1062.65 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.2506 mL | 21.2531 mL | 42.5062 mL |
| 5 mM | 0.8501 mL | 4.2506 mL | 8.5012 mL |
| 10 mM | 0.4251 mL | 2.1253 mL | 4.2506 mL |
Synonyms
