[CAS NO. 6338-55-2] NH2-PEG3

Name: NH2-PEG3
Brand: Arctom Scientific
SKU: AS590406

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PRODUCTS SPECIFICATIONS [6338-55-2]

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Catalog

AS590406

Brand

Arctom Scientific

CAS

6338-55-2

DESCRIPTION [6338-55-2]

Overview

MDL	MFCD07367495
Molecular Weight	149.19
Molecular Formula	C6H15NO3
SMILES	NCCOCCOCCO

For research use only. We do not sell to patients.

Summary

NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1) ^[1] .

IC50 & Target

PEGs

Appearance

Liquid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 670.29 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.7029 mL	33.5143 mL	67.0286 mL
5 mM	1.3406 mL	6.7029 mL	13.4057 mL
10 mM	0.6703 mL	3.3514 mL	6.7029 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (16.76 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (13.94 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (13.94 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Ohoka N,et al. Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins. ACS Chem Biol. 2019 Oct 16.

Synonyms

Ethanol, 2-[2-(2-aminoethoxy)ethoxy]-

2-[2-(2-Aminoethoxy)ethoxy]ethanol

Triethylene glycol monoamine

T₃EGMA

8-Amino-3,6-dioxa-1-octanol

Triglycolamine

MA 10

NSC 40760

8-Amino-3,6-dioxaoctanol

2-[2-(2-Hydroxyethoxy)ethoxy]ethylamine

3,6,9-Trioxadecylamine

2-[2-(2-Aminoethoxy)ethoxy]ethan-1-ol