[CAS NO. 63638-91-5] Brofaromine
PRODUCTS SPECIFICATIONS [63638-91-5]
DESCRIPTION [63638-91-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 310.19 |
| Molecular Formula | C14H16BrNO2 |
| SMILES | BrC1=CC(OC)=CC2=C1OC(C3CCNCC3)=C2 |
Summary
Brofaromine (CGP 11305A) is a monoamine oxidase ( MAO ) inhibitor with IC 50 of 0.2 μM for MAO-A .
IC50 & Target
IC50: 0.2 μM (MAO-A) [1]
In Vitro
In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC 50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC 50 range of Brofaromine is 0.01 μM to 0.1 μM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 805.96 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2238 mL | 16.1192 mL | 32.2383 mL |
| 5 mM | 0.6448 mL | 3.2238 mL | 6.4477 mL |
| 10 mM | 0.3224 mL | 1.6119 mL | 3.2238 mL |
Synonyms
