[CAS NO. 638213-98-6] AGL-2263
PRODUCTS SPECIFICATIONS [638213-98-6]
DESCRIPTION [638213-98-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 322.27 |
| Molecular Formula | C17H10N2O5 |
| SMILES | O=C(C1=CC(O)=C(O)C=C1)/C(C#N)=C/C2=CC=C(OC3=O)C(N3)=C2 |
1 Publications Citing Use of MCE
Summary
AGL-2263 is an insulin receptor and insulin-like growth factor (IGF) receptor inhibitor [1] [2] .
IC50 & Target
Insulin receptor [1] .
In Vitro
AGL-2263 (5 μM, for 1 h followed by insulin treatment for 24 h) inhibits IR and insulin could still induce phosphorylation of AKT and ERK1/2 after the IR inhibition [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [3]
| Cell Line: | Granulosa cells. |
| Concentration: | 5 μM. |
| Incubation Time: | For 1 h followed by insulin treatment for 24 h. |
| Result: | Insulin still induced phosphorylation of AKT and ERK1/2 after IR was inhibited by AGL2263. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 310.30 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1030 mL | 15.5149 mL | 31.0299 mL |
| 5 mM | 0.6206 mL | 3.1030 mL | 6.2060 mL |
| 10 mM | 0.3103 mL | 1.5515 mL | 3.1030 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (6.45 mM); Clear solution
References
- [1] Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705.
- [2] Hua Zhang, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014 Nov 3;24(21):2501-8.
- [3] Ying Han, et al. Insulin mitigates apoptosis of porcine follicular granulosa cells by downregulating BimEL. Reprod Biol. 2019 Sep;19(3):293-298.
