[CAS NO. 64-75-5] Tetracyclinehydrochloride

Name: Tetracyclinehydrochloride
Brand: Arctom Scientific
SKU: HY-B0474

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PRODUCTS SPECIFICATIONS [64-75-5]

Fulfillment

Catalog

HY-B0474

Brand

MCE

CAS

64-75-5

DESCRIPTION [64-75-5]

Overview

MDL	-
Molecular Weight	480.90
Molecular Formula	C22H25ClN2O8
SMILES	O[C@@]1(C(C(C(N)=O)=C2O)=O)[C@@]([C@@H]2N(C)C)([H])C[C@@]([C@](O)(C3=CC=C4)C)([H])C(C(C3=C4O)=O)=C1O.Cl

For research use only. We do not sell to patients.

19 Publications Citing Use of MCE

Summary

Tetracycline (hydrochloride) is a broad-spectrum antibiotic , exhibiting activity against a wide range of gram-positive and gram-negative bacteria .

IC50 & Target

Tetracycline

In Vitro

Tetracyclines are broad-spectrum agents, exhibiting activity against a wide range of gram-positive and gram-negative bacteria, atypical organisms such as chlamydiae, mycoplasmas, and rickettsiae, and protozoan parasites. Tetracyclines inhibit bacterial protein synthesis by preventing the association of aminoacyl-tRNA with the bacterial ribosome. Tetracyclines traverse the outer membrane of gram-negative enteric bacteria through the OmpF and OmpC porin channels, as positively charged cation (probably magnesium)-tetracycline coordination complexes ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The tetracyclines have applications for the treatment of infections in poultry, cattle, sheep, and swine. In some cases, e.g., for therapeutic treatment of large numbers of poultry reared on commercial farms, the antibiotics are added directly to feed or water or can be administered in aerosols. Tetracyclines could be used as growth promotion or growth enhancement. Tetracyclines are used in aquaculture to control infections in salmon, catfish, and lobsters ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01763437	The Cleveland Clinic	Chalazia\|Chalazion	March 2014	Early Phase 1
NCT04721626	Medical College of Wisconsin	Head and Neck Cancer	January 6, 2021
NCT02359331	Seoul National University Bundang Hospital	Helicobacter Infection	August 2014	Not Applicable
NCT00873808	Southwest Oncology Group\|National Cancer Institute (NCI)	Breast Cancer	October 2008
NCT03095378	University of Sao Paulo	Gingival Recession	March 10, 2014	Not Applicable
NCT00091247	Alliance for Clinical Trials in Oncology\|National Cancer Institute (NCI)	Unspecified Adult Solid Tumor, Protocol Specific	December 2004	Not Applicable
NCT04716426	University of Nove de Julho\|Santa Casa de Misericórdia de Porto Alegre	COVID-19	January 28, 2021	Not Applicable
NCT05219929	Johns Hopkins University	Post-Treatment Lyme Disease	November 2, 2022	Phase 2
NCT03139253	Yanqing Li\|Shandong University	Antimicrobial Susceptibility Testing\|Triple Therapy	May 30, 2017	Phase 4
NCT05431075	Shandong University\|Peking University Care Luzhong Hospital\|Yuncheng Hospital of Traditional Chinese Medicine\|Taierzhuang District People´s Hospital\|Zhengzhou Central Hospital\|Zibo Central Hospital	Helicobacter Pylori Infection	July 2022	Phase 4
NCT04678492	Xijing Hospital of Digestive Diseases	Gastritis\|Dyspepsia\|Helicobacter Pylori Infection\|Gastric Cancer\|Peptic Ulcer	December 20, 2020	Phase 4
NCT03708848	Shanghai Jiao Tong University School of Medicine	Helicobacter Pylori Infection	December 5, 2018	Phase 4
NCT04107194	University of Bari	Helicobacter Pylori Infection\|Antibiotic Resistant Infection\|Antibiotic Resistant Strain	January 14, 2020	Phase 3
NCT00361257	AIDS Clinical Trials Group\|National Institute of Allergy and Infectious Diseases (NIAID)\|Neurologic AIDS Research Consortium (NARC)	HIV Infections	March 2007	Phase 2
NCT02057926	Universitat Internacional de Catalunya	Ridge Preservation Technique	November 2009	Phase 2
NCT05250050	Shanghai Zhongshan Hospital	Helicobacter Pylori Infection	March 25, 2022	Phase 4
NCT03609892	Xijing Hospital of Digestive Diseases	Gastric Ulcer\|Chronic Gastritis\|Gastric Cancer\|Helicobacter Pylori Infection\|Gastritis	August 1, 2018	Phase 4
NCT01880515	Instituto Nacional de Cancerologia de Mexico	Skin Rash\|Lung Cancer	December 2010	Phase 2
NCT01010295	International Extranodal Lymphoma Study Group (IELSG)	Non-Hodgkin Lymphoma	September 2006	Phase 2
NCT04066257	HK inno.N Corporation	Healthy	January 17, 2019	Phase 1
NCT02159976	Seoul National University Bundang Hospital\|SK Chemicals Co., Ltd.\|Chong Kun Dang Pharmaceutical\|HK inno.N Corporation\|Green Cross Corporation	Helicobacter Pylori Infection	July 2014	Not Applicable
NCT01753856	Eli Lilly and Company	Osteoporosis	January 2013	Phase 4
NCT04527055	National Cheng-Kung University Hospital	Helicobacter Pylori Infection\|Dysbiosis\|Probiotics	May 6, 2020	Phase 4
NCT05620589	Shandong University\|Peking University Care Luzhong Hospital\|Yuncheng Hospital of Traditional Chinese Medicine\|Taierzhuang District People´s Hospital\|The First Affiliated Hospital of Zhengzhou University\|Zibo Central Hospital	Helicobacter Pylori Infection	November 11, 2022
NCT04810793	Shandong University\|Taian City Central Hospital\|Dezhou People´s Hospital\|Weifang Medical University\|The Affiliated Hospital of Qingdao University\|Shengli Oilfield Hospital	Helicobacter Pylori	July 1, 2020
NCT05049902	Shandong University\|Maternity and Child Care Health Center of Dezhou\|Heze Municipal 3rd people´s hospital\|Peking University Care Luzhong Hospital\|The First Affiliated Hospital with Nanjing Medical University\|The People´s Hospital of Jimo.Qingdao	Helicobacter Pylori Infection	September 21, 2021	Phase 4
NCT01742429	Shanghai Jiao Tong University School of Medicine	Cure Rate of Helicobacter Pylori Infection	November 2012	Phase 4
NCT05061732	Shanghai Zhongshan Hospital	Helicobacter Pylori Infection	September 30, 2021	Phase 4
NCT00347776	Johns Hopkins University\|National Eye Institute (NEI)\|Project ORBIS	Trichiasis	August 2001	Phase 4
NCT01792700	Seoul National University Bundang Hospital	Helicobacter Infections	January 2003	Phase 4
NCT03634605	Isfahan University of Medical Sciences	Primary Spontaneous Pneumothorax	May 5, 2015	Not Applicable
NCT04901117	Shandong University\|The Affiliated Hospital of Qingdao University\|The People´s Hospital of Guangrao\|Weihai Municipal Hospital\|Shandong Provincial Third Hospital\|Taian City Central Hospital\|Jining No.2 People´s Hospital\|Maternity and Child Care Health Center of Dezhou\|Zoucheng People´s Hospital\|Heze Municipal 3rd people´s hospital\|Yuncheng Chengxin Hospital\|Peking University Care Luzhong Hospital\|Qihe County City Hospital\|Weifang People´s Hospital\|Qilu Hospital of Shandong University\|Shandong Electric Power Central Hospital	Helicobacter Pylori Infection	June 2021	Phase 4
NCT00355459	University of Texas Southwestern Medical Center	Dry Eye Syndrome	August 2005	Not Applicable
NCT01293643	Merck Sharp & Dohme LLC	Vaginosis, Bacterial\|Candidiasis, Vulvovaginal	May 2010	Phase 3
NCT00003151	European Organisation for Research and Treatment of Cancer - EORTC\|University of Glasgow	Lymphoma	September 1997	Phase 2
NCT00591162	The University of Texas Medical Branch, Galveston	Burn	October 1992	Phase 2\|Phase 3
NCT03555526	National Taiwan University Hospital	H Pylori Infection	December 15, 2017	Phase 4
NCT00841854	Asan Medical Center\|Inje University\|Pacific Pharmaceuticals	Helicobacter Infection	June 2008	Phase 4
NCT02754583	University of California, San Francisco\|The Carter Center\|Amhara Public Health Institute\|Emory University\|National Eye Institute (NEI)	Trachoma	December 5, 2015	Phase 3
NCT01098448	The Forsyth Institute\|Göteborg University\|Boston University	Periodontitis	September 1999	Phase 3
NCT04730674	Zagazig University	Post-mastectomty Seroma	January 1, 2020	Not Applicable
NCT00889356	Zodiac Produtos Farmaceuticos S.A.	Candidiasis\|Bacterial Vaginosis	September 2009	Phase 3
NCT03632733	Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh	Keratotic Nodular Size	January 21, 2018	Phase 2
NCT03611920	University of Bern	Dental Trauma\|Avulsion\|Periodontal Regeneration\|Pulpal Regeneration\|Topical Dexamethasone\|Topical Tetracycline	August 14, 2000
NCT01668927	Shanghai Jiao Tong University School of Medicine	Functional Dyspepsia\|Scarred Peptic Ulcer	July 2012	Phase 4
NCT02175927	Shanghai Jiao Tong University School of Medicine	Helicobacter Pylori Treatment Failure	July 2014	Phase 4
NCT02988089	Shandong University\|Shandong Provincial Hospital\|General Hospital of Jinan Military Region\|Binzhou People´s Hospital\|Liaocheng People´s Hospital	Helicobacter Pylori Infection\|Antimicrobial Susceptibility Testing	April 20, 2017	Phase 4
NCT05018923	Shanghai Zhongshan Hospital	Helicobacter Pylori Infection	August 24, 2021	Phase 4
NCT03146325	The University of Texas Health Science Center, Houston\|Baylor College of Medicine	Helicobacter Pylori Infection	November 2012	Phase 4
NCT01481844	Soroka University Medical Center	Optimization of Second Line Treatment Protocol for H Pylori Eradication	November 2011	Phase 3
NCT03908892	Guangzhou University of Traditional Chinese Medicine	Paronychia	June 12, 2019	Not Applicable
NCT02576652	Amgen	Osteoporosis	December 22, 2015	Phase 4
NCT00002682	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)	Lymphoma	August 10, 1995	Phase 2
NCT03208426	National Taiwan University Hospital	Helicobacter Pylori Infection	October 1, 2017	Phase 4

Appearance

Solid

Source

Streptomyces

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL ( 129.96 mM ; Need ultrasonic)

H ₂ O : 50 mg/mL ( 103.97 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0794 mL	10.3972 mL	20.7943 mL
5 mM	0.4159 mL	2.0794 mL	4.1589 mL
10 mM	0.2079 mL	1.0397 mL	2.0794 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.33 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Chopra I, et al.Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance.Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60

Synonyms

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride (1:1), (4S,4aS,5aS,6S,12aS)-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, [4S-(4α,4aα,5aα,6β,12aα)]-

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aS,5aS,6S,12aS)-

Cancycline-250

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Partrex

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