[CAS NO. 64241-34-5] Cadralazine

Name: Cadralazine
Brand: Arctom Scientific
SKU: AS499696

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PRODUCTS SPECIFICATIONS [64241-34-5]

Distributor

Catalog

AS499696

Brand

Arctom Scientific

CAS

64241-34-5

DESCRIPTION [64241-34-5]

Overview

MDL	MFCD00865833
Molecular Weight	283.33
Molecular Formula	C12H21N5O3
SMILES	O=C(NNC1=NN=C(N(CC(C)O)CC)C=C1)OCC

For research use only. We do not sell to patients.

Summary

Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 882.36 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5295 mL	17.6473 mL	35.2945 mL
5 mM	0.7059 mL	3.5295 mL	7.0589 mL
10 mM	0.3529 mL	1.7647 mL	3.5295 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (7.34 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (7.34 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (7.34 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] K Takeyama, et al. Antihypertensive activity of cadralazine in experimental hypertensive rats. Arch Int Pharmacodyn Ther. Jan-Feb 1988;291:163-74.

Synonyms

Hydrazinecarboxylic acid, 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-, ethyl ester

ISF 2469

Cadralazine

DC 826

CGP 18684E

Presmode

Cadral

Cadraten

Cadrilan