[CAS NO. 64421-28-9] Shanzhiside methyl ester
PRODUCTS SPECIFICATIONS [64421-28-9]
DESCRIPTION [64421-28-9]
Overview
| MDL | MFCD00017416 |
|---|---|
| Molecular Weight | 406.38 |
| Molecular Formula | C17H26O11 |
| SMILES | O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@]3(O)C)([H])[C@@]([C@H](O)C3)([H])C(C(OC)=O)=CO2 |
Summary
Shanzhiside methy lester is isolated from lamiophlomis rotata . Shanzhiside methyl ester is a small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and has the ability to induce anti-allodynic tolerance [1] .
IC50 & Target
IC50: GLP-1 receptor [1]
In Vivo
Shanzhiside methyl ester exerts dose-dependent and long-lasting (>4 h) anti-allodynic effects in spinal nerve injury-induced neuropathic rats, with a maximal inhibition of 49% and a projected ED
50
of 40.4 μg
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 246.08 mM ; Need ultrasonic)
H 2 O : 50 mg/mL ( 123.04 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4608 mL | 12.3038 mL | 24.6075 mL |
| 5 mM | 0.4922 mL | 2.4608 mL | 4.9215 mL |
| 10 mM | 0.2461 mL | 1.2304 mL | 2.4608 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (123.04 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution
