[CAS NO. 6515-37-3] 4'-Hydroxyflavanone

Name: 4'-Hydroxyflavanone
Brand: Arctom Scientific
SKU: AS061038

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PRODUCTS SPECIFICATIONS [6515-37-3]

Distributor

Catalog

AS061038

Brand

Arctom Scientific

CAS

6515-37-3

DESCRIPTION [6515-37-3]

Overview

MDL	MFCD00017705
Molecular Weight	240.25
Molecular Formula	C15H12O3
SMILES	O=C1CC(C2=CC=C(O)C=C2)OC3=CC=CC=C13

For research use only. We do not sell to patients.

Summary

4'-Hydroxyflavanone is an inhibitor of SREBP maturation and lipid synthesis. 4'-Hydroxyflavanone is a synthetic analogue of flavanone, has potential for hepatic steatosis and dyslipidemia research ^[1] .

Appearance

Solid

Source

Aspergillus niger

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 416.23 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1623 mL	20.8117 mL	41.6233 mL
5 mM	0.8325 mL	4.1623 mL	8.3247 mL
10 mM	0.4162 mL	2.0812 mL	4.1623 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.41 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.41 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.41 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Shingo Miyata, et al. 4'-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis. FEBS Lett. 2012 Jun 21;586(13):1778-82.

Synonyms

4H-1-Benzopyran-4-one, 2,3-dihydro-2-(4-hydroxyphenyl)-

Flavanone, 4′-hydroxy-

2,3-Dihydro-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

4′-Hydroxyflavanone

(±)-4′-Hydroxyflavanone

STX 310

2-(4-Hydroxyphenyl)chroman-4-one

2-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one

2-(4-Hydroxyphenyl)-2,3-dihydrochromen-4-one