[CAS NO. 65869-63-8] Bis-PEG2-NHSester

Name: Bis-PEG2-NHSester
Brand: Arctom Scientific
SKU: AS270332

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PRODUCTS SPECIFICATIONS [65869-63-8]

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Catalog

AS270332

Brand

Arctom Scientific

CAS

65869-63-8

DESCRIPTION [65869-63-8]

Overview

MDL	MFCD20229443
Molecular Weight	400.34
Molecular Formula	C16H20N2O10
SMILES	O=C(ON1C(CCC1=O)=O)CCOCCOCCC(ON2C(CCC2=O)=O)=O

For research use only. We do not sell to patients.

Summary

Bis-PEG2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-drug-conjugation (ADC).

IC50 & Target

Non-cleavable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 249.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4979 mL	12.4894 mL	24.9788 mL
5 mM	0.4996 mL	2.4979 mL	4.9958 mL
10 mM	0.2498 mL	1.2489 mL	2.4979 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.24 mM); Clear solution

* All of the co-solvents are available by MCE.

Synonyms

2,5-Pyrrolidinedione, 1,1′-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis-

[CAS NO. 65869-63-8] Bis-​PEG2-​NHSester