[CAS NO. 6659-45-6] Dihydrorotenone

Name: Dihydrorotenone
Brand: Arctom Scientific
SKU: AS051403

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PRODUCTS SPECIFICATIONS [6659-45-6]

Distributor

Catalog

AS051403

Brand

Arctom Scientific

CAS

6659-45-6

DESCRIPTION [6659-45-6]

Overview

MDL	-
Molecular Weight	396.43
Molecular Formula	C23H24O6
SMILES	O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC)C=C32)([H])OC4=C5C(O[C@@H](C(C)C)C5)=CC=C14

For research use only. We do not sell to patients.

Summary

Dihydrorotenone, a natural pesticide, is a potent mitochondrial inhibitor. Dihydrorotenone probably induces Parkinsonian syndrome. Dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 63.06 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5225 mL	12.6126 mL	25.2251 mL
5 mM	0.5045 mL	2.5225 mL	5.0450 mL
10 mM	0.2523 mL	1.2613 mL	2.5225 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.31 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhang J, et al. The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway. PLoS One. 2013 Jul 26;8(7):e69911.

Synonyms

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-, (2R,6aS,12aS)-

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aαH)-one, 1,2,12,12aα-tetrahydro-2α-isopropyl-8,9-dimethoxy-

[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethyl)-, [2R-(2α,6aα,12aα)]-

(2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethyl)[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Dihydrorotenone

1′,2′-Dihydrorotenone

NSC 351138

NSC 53866