[CAS NO. 67605-85-0] N-Butanoyl-L-homoserinelactone
PRODUCTS SPECIFICATIONS [67605-85-0]
DESCRIPTION [67605-85-0]
Overview
| MDL | MFCD12912262 |
|---|---|
| Molecular Weight | 171.19 |
| Molecular Formula | C8H13NO3 |
| SMILES | CCCC(N[C@H]1CCOC1=O)=O |
Summary
N-Butanoyl-L-homoserine lactone (C4-HSL) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N-Butanoyl-L-homoserine lactone has antibacterial activity and is used in antibacterial biofilm [1] . N-Butanoyl-L-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa [2] [3] .
IC50 & Target
|
Cleavable |
In Vitro
The dissociation constant (K d value) of aptamer binding to N-Butanoyl-L-homoserine lactone (C4-HSL) is 28.47 nM [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 584.15 mM ; Need ultrasonic)
H 2 O : 20 mg/mL ( 116.83 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.8415 mL | 29.2073 mL | 58.4146 mL |
| 5 mM | 1.1683 mL | 5.8415 mL | 11.6829 mL |
| 10 mM | 0.5841 mL | 2.9207 mL | 5.8415 mL |
References
- [1] Keith Alan Charlton, et al. Methods for the Treatment of an Infectious Bacterial Disease with an Anti-Lactone or Lactone Derived Signal Molecules Antibody. US20130045208A1
- [2] Zhao M, et al. C4-HSL aptamers for blocking qurom sensing and inhibiting biofilm formation in Pseudomonas aeruginosa and its structure prediction and analysis. PLoS One. 2019 Feb 19;14(2):e0212041.
- [3] Feng Sun, et al. Advance of the diversity of bacterial quorum sensing and quorum quenching. National Natural Science Foundation of China. Published online 9 October 2018.
