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[CAS NO. 69-57-8] Penicillin G sodium salt
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1463 |
| Brand: | MCE |
| CAS: | 69-57-8 |
Overview
| MDL | MFCD00069666 |
|---|---|
| Molecular Weight | 356.37 |
| Molecular Formula | C16H17N2NaO4S |
| SMILES | O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(CC3=CC=CC=C3)=O)N1C2=O)O[Na] |
7 Publications Citing Use of MCE
- [1]Theranostics. 2022 Jan 1;12(3):1187-1203.
- [2]Cancers (Basel). 2022 Sep 28;14(19):4740.
- [3]Chemosphere. 2019 Jun;225:378-387.
- [4]EBioMedicine. 2022 Apr;78:103943.
- [5]Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702.
- [6]Front Physiol. 2020; 11: 605982.
- [7]Eur Rev Med Pharmaco. 2019 Sep;23(17):7419-7429.
Summary
Penicillin G sodium salt is a typical β-lactam antibiotic .
IC50 & Target
|
β-lactam
|
In Vitro
The Ultraviolet-visible (UV-Vis) absorption spectrum of the Penicillin G sodium salt-TEM-1 system is markedly different to that of Penicillin G sodium salt and TEM-1 β-lactamase, indicating the formation of new complexes between Penicillin G sodium salt and TEM-1 β-lactamase. The UV-Vis absorption of TEM-1 β-lactamase increases and a slight red-shift occurs as the concentration of Penicillin G sodium salt increasing, indicating that the interaction between Penicillin G sodium salt and TEM-1 β-lactamase results in subtle conformational changes of TEM-1 β-lactamase [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
In the logistic regression model, the probability of a positive swab in the control group is 1.6 times higher than that in the pigs treated with Penicillin G sodium salt (P<0.05). In the control group, the risk of a swab having 10 to 99 colonies per plate, compare to having zero per plate, is 2.3 times greater than that in the pigs treated with Penicillin G sodium salt (P=0.022) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT05211024 | Children´s Hospital Medical Center, Cincinnati|Uganda Heart Institute, Kampala, Uganda|Murdoch Children´s Research Institute, Melbourne Australia |
Rheumatic Heart Disease
|
January 28, 2022 | |
| NCT03660488 | University of California, Los Angeles|AIDS Healthcare Foundation |
Syphilis|Early Syphilis
|
September 3, 2018 | Phase 2 |
| NCT03612557 | Pfizer |
Healthy
|
August 20, 2018 | Phase 1 |
| NCT02871505 | Peking Union Medical College Hospital |
Syphilis
|
August 2016 | Phase 4 |
| NCT01310361 | Azad University of Medical Sciences |
Streptococcal Sore Throat
|
January 2004 | Phase 1 |
| NCT02857959 | Jun Li|Peking Union Medical College Hospital |
Syphilis
|
August 2016 | Phase 4 |
| NCT02611765 | Baylor College of Medicine |
Syphilis
|
September 2008 | Phase 4 |
| NCT03632642 | The University of Queensland |
Staphylococcus Aureus
|
July 1, 2019 | Phase 4 |
| NCT03346525 | Children´s National Research Institute|Thrasher Research Fund|University of Cape Town|Uganda Heart Institute|Karp Family Foundation|Gift of Life International|Murdoch Childrens Research Institute |
Rheumatic Heart Disease in Children|Latent Rheumatic Heart Disease|Rheumatic Heart Disease|Heart Diseases
|
June 26, 2018 | Phase 2 |
| NCT00000648 | National Institute of Allergy and Infectious Diseases (NIAID)|Hoffmann-La Roche |
HIV Infections|Neurosyphilis
|
Not Applicable | |
| NCT04876131 | Murdoch Childrens Research Institute|Royal Children´s Hospital |
Complicated Urinary Tract Infection|Infection|Pediatric Infectious Disease
|
May 30, 2022 | Phase 4 |
Appearance
Solid
Source
Penicillium
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 280.61 mM )
H 2 O : ≥ 100 mg/mL ( 280.61 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8061 mL | 14.0304 mL | 28.0607 mL |
| 5 mM | 0.5612 mL | 2.8061 mL | 5.6121 mL |
| 10 mM | 0.2806 mL | 1.4030 mL | 2.8061 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (280.61 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (7.02 mM); Clear solution
References
- [1] Yang J, et al. Spectroscopic analysis and docking simulation on the recognition and binding of TEM-1 β-lactamase with β-lactam antibiotics. Exp Ther Med. 2017 Oct;14(4):3288-3298.
- [2] Byra C, et al. Decreased mortality of weaned pigs with Streptococcus suis with the use of in-water potassium penicillin G. Can Vet J. 2011 Mar;52(3):272-6.
Synonyms
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