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[CAS NO. 70-26-8] L-Ornithine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1352 |
| Brand: | MCE |
| CAS: | 70-26-8 |
Overview
| MDL | MFCD00242584 |
|---|---|
| Molecular Weight | 132.16 |
| Molecular Formula | C5H12N2O2 |
| SMILES | N[C@@H](CCCN)C(O)=O |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
Human Endogenous Metabolite
|
Microbial Metabolite
|
In Vitro
L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca
2+
signaling in HK-2 cells
[2]
.
L-Ornithine (10 mM) activates TRPC channels mediated Ca
2+
entry pathway in HK-2 cells
[2]
.
L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway
[2]
.
L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H
2
O
2
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT05042024 | Ukrainian Medical Stomatological Academy |
Periodontitis
|
October 20, 2017 | Phase 3 |
| NCT00433368 | Aga Khan University |
Hepatic Encephalopathy
|
October 2003 | Phase 3 |
| NCT00470314 | All India Institute of Medical Sciences, New Delhi |
Acute Liver Failure
|
January 2005 | Phase 2 |
| NCT02158182 | Hospital General de Mexico |
Hepatic Encephalopathy
|
July 2014 | Phase 4 |
| NCT00305591 | Imperial College London|Royal College of Physicians|Paddington Charitable Estates Educational Fund|University of London |
Cirrhosis|Hepatic Encephalopathy
|
March 2006 | Not Applicable |
| NCT01722578 | Dayanand Medical College and Hospital |
Cirrhosis of Liver|Hepatic Encephalopathy
|
December 2013 | Phase 4 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H 2 O : 50 mg/mL ( 378.33 mM ; Need ultrasonic)
DMSO : 1.3 mg/mL ( 9.84 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 7.5666 mL | 37.8329 mL | 75.6659 mL |
| 5 mM | 1.5133 mL | 7.5666 mL | 15.1332 mL |
| 10 mM | 0.7567 mL | 3.7833 mL | 7.5666 mL |
References
- [1] Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43.
- [2] Shin S, et al. l-ornithine activates Ca2+ signaling to exert its protective function on human proximal tubular cells. Cell Signal. 2020 Mar;67:109484.
Synonyms
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